Preface xiii

Part 1 Strategies of Affinity Materials

1 Recent Molecularly Imprinted Polymer-based Methods for Sample Preparation 3
Antonio Mart?n-Esteban

1.1 Introduction 3
1.2 Molecularly Imprinted Solid-phase Extraction 6
1.3 Molecularly Imprinted Solid-phase Microextraction 14
1.4 Molecularly Imprinted Stir Bar Sorptive Extraction 17
1.5 Other Formats 18
1.6 Conclusions 20
References 21

2 A Genuine Combination of Solvent-free Sample Preparation Technique and Molecularly Imprinted Nanomaterials 29
Santanu Patra, Ekta Roy, Rashmi Madhuri and Prashant K. Sharma

2.1 Introduction 30
2.2 Molecularly Imprinted Polymer Modified Fiber for Solid-phase Microextraction 40
2.3 In-tube Solid-phase Microextraction Technique 55
2.4 Monolithic Fiber 58
2.5 Micro-solid-phase Extraction 70
2.6 Stir-bar Sorptive Extraction 73
2.7 Conclusion and Future Scope 76
Acknowledgments 76
Abbreviations 77
References 78

3 Fluorescent Molecularly Imprinted Polymers 89
Kornelia Gawlitza, Wei Wan, Sabine Wagner and Knut Rurack

3.1 Introduction 89
3.2 Classes of Emitters to Endow MIPs with Fluorescence 91
3.3 Fluorescent Molecularly Imprinted Silica 108
3.4 Post-imprinting of MIPs 111
3.5 fMIPs as Labels 113
3.6 Formats for fMIPs 115
3.7 Conclusion 119
References 120

4 Molecularly Imprinted Polymer-based Micro- and Nanotraps for Solid-phase Extraction 129
R?dvan Say, R?stem Ke?ili and Arzu Ers?z

4.1 Introduction 130
4.2 MIPs as SPE Materials 130
4.3 Conclusions 149
References 153

5 Imprinted Carbonaceous Nanomaterials: A Tiny Looking Big Thing in the Field of Selective and Secific Analysis 165
Ekta Roy, Santanu Patra, Rashmi Madhuri and Prashant K. Sharma

5.1 Introduction 166
5.2 Graphene-modified Imprinted Polymer 179
5.3 Carbon Nanotubes-modified Imprinted Polymer 190
5.4 Combination of graphene, CNTs, and MIPs 197
5.5 Graphene Quantum Dots and/or Carbon Dots 198
5.6 Fullerene 201
5.7 Activated carbon 202
5.8 Conclusions 203
Acknowledgments 204
List of abbreviations 204
References 205

6 Molecularly Imprinted Materials for Fiber-optic Sensor Platforms 217
Yavuz Orhan Yaman, Necdet Ba?aran, K?bra Karayagiz, Zafer Vatansever, Cengiz Yegin, ?nder Haluk Tekba? and M?frettin Murat Sari

6.1 Introduction 218
6.2 Material Aspect: Morphology and Physical Forms of MIPs in FO Sensors 223
6.3 Molecularly Imprinting Technology for Fiber-optic Sensors 231
6.4 State-of-the-art Fiber-optic Sensors Applications Using Molecularly Imprinted Materials 268
6.5 Conclusion 273
References 274

Part 2 Rational Design of MIP for Advanced Applications

7 Molecularly Imprinted Polymer-based Sensors for Biomedical and Environmental Applications 285
Anca Florea, Oana Hosu, Bianca Ciui and Cecilia Cristea

7.1 Introduction 285
7.2 Molecularly Imprinted Polymers for Analytes of Biomedical Interest 296
7.3 Molecularly Imprinted Polymers for Analytes of Environmental Interest 306
7.4 Conclusion 314
Acknowledgments 316
References 316

8 Molecularly Imprinted Polymers: The Affinity Adsorbents for Environmental Biotechnology 327
Bo Mattiasson and Gizem Ert?rk

8.1 Introduction 327
8.2 Molecularly Imprinted Polymers 329
8.3 Monomers 329
8.4 Cross-linking Agents 331
8.5 Mode of Polymerization 332
8.6 Cryogels 334
8.7 Process Technology 336
8.8 Applications 338
References 345

9 Molecular Imprinting Technology for Sensing and Separation in Food Safety 353
Baran ?nal Ulusoy, Mehmet Odaba?i and Ne?e Hayat Aksoy

9.1 Food Safety 354
9.2 Food Analysis 355
9.3 Current Separation Methods Used for Food Safety Purposes 356
9.4 What Is MIP? 357
9.5 MIP Applications Used for Food Safety Purposes 359
References 377

10 Advanced Imprinted Materials for Virus Monitoring 389
Zeynep Altintas

10.1 Introduction 390
10.2 Virus Imprinting 393
10.3 Artificial MIP Receptors for Viruses 398
10.4 Virus Monitoring and Detection Using Biomimetic Sensors 399
10.5 Virus Imprinting for Separation Technologies 401
10.6 Conclusions 405
References 406

11 Design and Evaluation of Molecularly Imprinted Polymers as Drug Delivery Systems 413
Andr? Lu?s Morais Ruela and Gislaine Ribeiro Pereira

11.1 Introduction 414
11.2 Synthesis and Characterization of MIPs Intended for Drug Release Using Non-covalent Approaches 418
11.3 Design and Evaluation of Drug Delivery Systems Based on MIPs 436
11.4 Conclusions 445
References 446

12 Molecularly Imprinted Materials for Controlled Release Systems 455
Yagmur Yegin, G?khan Yilmaz, ?mer Karako?, Cengiz Yegin, Servet ?ete, Mustafa Akbulut and M?frettin Murat Sari

12.1 Introduction 456
12.2 Selectivity, Release Mechanism and Functionality of MIPs-based CR Systems 459
12.3 Molecularly Imprinted Polymers Production for Controlled Release 482
12.4 Controlled Release Applications Using Molecularly Imprinted Materials-based Controlled Release 491
12.5 Conclusion 506
References 507

13 Molecular Imprinting: The Creation of Biorecognition Imprints on the Biosensor Surfaces 523
Gizem Ert?rk and Bo Mattiasson

13.1 Introduction 523
13.2 Molecular Imprinting 524
13.3 Microcontact Imprinting 525
13.4 Capacitive Biosensors 529
13.5 Surface Plasmon Resonance Biosensors 541
13.6 Concluding Remarks 549
References 550

14 Molecular Imprinted Polymers for Sensing of Volatile Organic Compounds in Human Body Odor 561
Sunil Kr. Jha

14.1 Introduction 562
14.2 MIP-QCM Sensor Array Preparation 573
14.3 Chemical Vapor Sensing 576
14.4 Analysis Outcomes 603
14.5 Conclusion 624
Acknowledgments 624
References 624

15 Development of Molecularly Imprinted Polymer-based Microcantilever Sensor System 637
Meltem Okan and Memed Duman

15.1 Introduction to Mass Sensors 637
15.2 Principles of Mass Sensors 640
15.4 Molecularly Imprinted Polymer Technology 655
15.5 Molecularly Imprinted Polymer-based QCM Sensors 658
15.6 Ongoing Studies on Molecularly Imprinted Polymers-based Microcantilevers 661
Acknowledgments 669
References 669