Название: Actin Polymerization in Apicomplexan: A Structural, Functional and Evolutionary Analysis Автор: Avinash Kale Издательство: Springer Singapore Год: 2019 Формат: pdf Страниц: 169 Размер: 10,7 МБ Язык: English
This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements.
The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CP? and CP?), cyclase-associated protein (CAP) and coronin 13–24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design.
Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.