Part I An Integrated View of Breast Cancer Biology

1 Fundamental Pathways In Breast Cancer 1: Signaling from the Membrane
Yekaterina Poloz. Ryan J.O. Dowling, and Vuk Stambolic
2 Fundamental Pathways In Breast Cancer 2: Maintenance of Genomic Stability
Chiara Gorrini and Так W. Mak
3 Fundamental Pathways In Breast Cancer 3: Estrogen Biology
Luca Magnani and Darren K. Patten
4 Fundamental Pathways In Breast Cancer 4: Signaling to Chromatin In Breast Development
Luca Mazzarella and Pier Giuseppe Pelicci
5 Breast Cancer Microenvironment and the Metastatic Process
George Sflomos and Cathrin Brisken
6 Mouse Models of Breast Cancer: Deceptions that Reveal the Truth
Joana Pinto Couto and Mohamed Bentires-Alj

Part II Epidemiology, Genetics and Prevention

7 Epidemiology. Lifestyle, and Environmental Factors
Patrick Maisonneuve
8 Breast Cancer Genetics
Ana Carolina Ribeiro Chaves de Gouvea and Judy E. Garber
9 Chemopreventlon
Andrea De Censi. Bernardo Bonanni. and Massimiliano Cazzaniga
10 Surgical Prevention
Paolo Veronesi and Nickolas Peradze

Part III Pathology: Standard and Molecular Diagnostics

11 Premallgnant and Pre-lnvaslve Lesions of the Breast
Elena Guerini-Rocco and Nicola Fusco
12 Prognostic and Predictive Role of Genetic Signatures
Giancarlo Pruneri and Francesca Boggio
13 Special Types of Breast Cancer and Non-eplthellal Tumors
Giovanni Mazzarol and Sara Pirola
14 Pathology After Neoadjuvant Treatments
W. Fraser Symmans
15 Breast Cancer Genomics
Maurizio Scaltriti
16 The Pathology Report
Andrea Vingiani and Giuseppe Viale

Part IV Imaging

17 Radiological Screening of Breast Cancer: Evolution
Alfonso Frigcrio. Francesco Sardanclli. and Franca Podo
18 Innovation In Breast Cancer Radiology
Rumana Rahim. Michael J. Michell, Viviana Londero, Chiara Zuiani, Martina Zanotel, Massimo Bazzocchi, and Christiane K. Kuhl
19 Nuclear Medicine In the Clinical Management (ROLL, SNB, and PET)
Giovanni Paganelli, Federica Matteucci, and Laura Gilardi
20 One-Step Systemic Staging for Patients with Breast Cancer
Giuseppe Petralia and Anwar R. Padhani
21 Imaging Findings After Surgery
Silvia Perez Rodrigo and Elizabeth A. Morris
22 Integrated Breast Biopsy for Best Radiological Diagnosis of Breast Cancer
Enrico Cassano and Chiara Trentin

Part V Oncological Surgery

23 Conservative Surgery
Umberto Veronesi
24 The Conservative Mastectomy
Alberto Luini
25 Surgical Treatment of Local Recurrence In Breast Cancer Patients
Jose Vila, Francisco Ripoll. and Oreste D. Gentilini
26 Management of the Axilla
Viviana Galimberti
27 Management of Intraepithelial Disease
Antonio Toesca
28 Breast-Conserving Surgery After Neoadjuvant Therapy
Mahdi Rezai and Stefan Kraemer
29 Surgical Treatment of the Primary I\imor In Patients with Metastatic Breast Cancer (Stage IV Disease)
Mattia Intra
30 Breast Cancer In Lymphoma Survivors
Mattia Intra and Denise Mattar Fanianos
31 Surgery of Metastases In Stage IV Breast Cancer
Elisabctta Pennacchioli, Gianluca Varano, Franco Orsi, Pierpaolo Prestianni, Gianmarco Orsolini, and Angela Cioffi

Part VI Plastic and Reconstructive Surgery

32 Oncoplastlc Surgery
Cicero Urban and Mario Rietjens
33 Delayed Breast Reconstruction
Cicero Urban and Flavia Kuroda
34 Immediate Breast Reconstruction (Direct to Implant)
Mario Rietjens, Pietro Loschi, and Leonardo Pires Novais Dias
35 Breast Reconstruction with Tissue Expander and Definitive Implant Replacement
Thomas H.S. Fysh and R. Rainsbury
36 The Pedicled TRAM Flap In Breast Reconstruction
Glyn Jones
37 Breast Reconstruction with Free Flaps
Fabio Santanelli di Pompeo, Benedetto Longo, and Rosaria Laporta
38 Contralateral Breast Management
Marco Klinger. Luca Maione, Silvia Giannasi. Valeria Bandi, Barbara Banzatti, Alessandra Veronesi, Barbara Catania, Valeriano Vinci, Andrea Lisa, Guido Cornegliani, Micol Giaccone, Mattia Siliprandi, Fabio Caviggioli, and Francesco Klinger
39 Lipofllllng
J.Y. Petit, V. Lohsiriwat, and M. Rietjens
40 Breast Reconstruction with Biological and Non-blologlcal Meshes and Matrices
Rachel Rolph and Jian Farhadi
41 How to Manage Complications In Breast Reconstruction
Francesca De Lorenzi

Part VII Medical Oncology

42 Adjuvant Systemic Therapies by Subtypes: Guidelines
Antonella Palazzo and Marco Colleoni
43 Primary Systemic Therapies: Guidelines
Jenny Furlanetto and Gunter von Minckwitz
44 Treatment of Advanced Disease: Guidelines
Rosario Andre, Simona Ruxandra Volovat, and Fatima Cardoso
45 Endocrine Therapies In the Adjuvant and Advanced Disease Settings
Olivia Pagani
46 Chemotherapy Regimens In the Adjuvant and Advanced Disease Settings
Christopher D. Hart, Laura Biganzoli. and Angelo Di Leo
47 Antl-HKR2 Therapies In the Adjuvant and Advanced Disease Settings
Elisabetta Munzone
48 Adjuvant Treatment with Bone-Targeting Agents (Blsphosphonates and Antl-RANK-Ligand Antibody)
Michael Gnant
49 Systemic Treatment for Specific Medical Situations
Silvia Dellapasqua

Part VIII Radiotherapy

50 Conceptual Basis and Principles of Radiation Oncology
Roberto Orecchia
51 Whole-Breast Irradiation Following Breast-Conserving Surgery for Invasive Breast Cancer
Anna Kirby
52 Whole-Breast Radiation Following Breast-Conserving Surgery In Nonlnvaslve Cancer
Beryl McCormick
53 Post mastectomy Radiation Therapy of Early Breast Cancer
Birgitte Vrou OfTerscn and Mette Skovhus Thomsen
54 Concurrent Use of Radiation Therapy and Targeted Molecules In the Breast Cancer Treatment
Youlia M. Kirova and Alain Fourquet
55 Accelerated Partial Breast Irradiation
Nina N. Sanford and Alphonse G. Taghian
56 Intraoperative Radiotherapy with Electrons (ELIOT)
Maria Cristina Leonardi
57 Radiotherapy for Metastatic Lesions
Per Karlsson and Dan Lundstedt

Part IX Special Conditions Requiring Multidisciplinary Approaches

58 Emergencies In Breast Cancer
Lorenzo Gianni, Maria Vittoria Stefania Nicoletti, and Valentina Arcangcli
59 Breast Cancer (Diagnosed) During Pregnancy: Adapting Recent Advances In Breast Cancer Care for Pregnant Patients
Sibylle Loibk, Andre Schmidt, Oreste D. Gentilink, Bella Kaufman, Christine Kuhl, Carsten Denkert, Gunter von Minckwitz, Anastasia Parokonnaya, Hanne Stensheim, Christoph Thomssen, Kristel van Calsteren, Philip Poortmans, Paul Berveiller, Udo Markert, and Frederic Amant
60 Chest Wall Disease: The Clinical Continuum Between Inflammatory and Lymphangltlc Breast Cancer
Giuseppe Curigliano
61 Fertility Issues In Patients with Breast Cancer or Survivors
Matteo Lambertini, Hatem A. Azim Jr. and Fedro A. Peccatori
62 Breast Cancer and Sexuality with Focus In Young Women: From Evidence-Based Data to Women’s Wording to Treatment Perspectives
Alessandra Graziottin
63 Male Breast Cancer
Laura Ottini and Carlo Capalbo
64 Treatment of Central Nervous System Involvement
E. Munzone, C. Casali, M. Del Bene, and F. Di Meco
65 Follow-Up of Patients with Breast Cancer
Lorenzo Gianni, Alessandra Affatato, and Davide Tassinari

Part X Investigating New Drugs and Immunological Agents In Breast Cancer

66 Targeting Immune Checkpoint
Angela Esposito and Giuseppe Curigliano
67 Targeting PI3К/AKT/mTOR Pathway
Carmen Criscitiello and Giuseppe Curigliano
68 Targeting Genome Instability and DNA Repair
Marzia Locatelli and Giuseppe Curigliano
69 Targeting the CDK4/6 Pathway In Breast Cancer
Luca Malorni, Ilenia Migliaccio, Cristina Guarducci, Martina Bonechi, and Angelo Di Leo
70 Targeting FGFR Pathway In Breast Cancer
Carmen Criscitiello. Angela Esposito, and Giuseppe Curigliano
71 Integrating Next-Generation Sequencing Data In Trial Design
Giuseppe Curigliano, Angela Esposito, Marzia Locatelli, and Carmen Criscitiello

Part XI Investigational and Miscellaneous Approaches

72 Lifestyle and Breast Cancer
Rowan T. Chlebowski
73 Psychological Support In Breast Cancer Patients: A Personalized Approach
Chiara Fioretti, Ketti Mazzocco, and Gabriel la Pravettoni
74 HIFU and Radio Frequency as Alternatives to Surgery
Franco Orsi and Giovanni Mauri
75 Hyperthermia with Radiotherapy and with Systemic Therapies
J. van der Zee and G.C. van Rhoon
76 Electrochemotherapy of Breast Cancer
Luca G. Campana, Louise Wichmann Matthiessen, Marko Snoj, and Gregor Sersa
77 Circulating mIRNA In Early Diagnosis
Fabrizio Bianchi
78 Relevance of Stem Cells
Salvatore Pece, Maria Grazia Malabarba, Pier Paolo Di Fiore, and Daniela Tosoni

Part XII Blostatlstlcs and Blolnformatlcs

79 Subgroup Analyses and Information from Clinical Trials on Breast Cancer
Wai-Ki Yip
80 The Methodology of Meta-Analyses and Its Potential Contribution to Patient Care
di Sara Gandini
81 Trial Designs and Blostatlstlcs for Molecular-Targeted Agents
William T. Barry
82 Blolnformatlcs for Clinical Use In Breast Cancer
Fabrizio Bianchi