 Название: Drug-Induced Liver Toxicity
Автор: Minjun Chen, Yvonne Will
Издательство: Humana Press
Год: 2018
ISBN: 9781493976775
Серия: Methods in Pharmacology and Toxicology
Формат: epub, pdf
Страниц: XX, 667
Размер: 25,9 mb
Язык: English
This book provides a comprehensive view of the methodologies used for the study of liver toxicity encountered throughout the whole life cycle of a drug, from drug discovery, to clinical trial, post-marketing, and even clinical practice. Organized into six sections, the first section introduces the mechanisms contributing to drug-induced liver toxicity. The second and third section explore in silico and in vitro approaches used to help mitigate hepatotoxicity liability at the early stages of drug development. The fourth section describes methodologies applied in regulatory processes, including preclinical studies, clinical trials, and post-marketing surveillance. The fifth section discusses clinical hepatotoxicity. Emerging technologies are examined in the final section. As a volume in the Methods in Pharmacology and Toxicology series, chapters include the kind of expert advice that will lead to optimal results.
Authoritative and practical, Drug-Induced Liver Toxicity serves all those who aim to improve assessment and understanding of hepatotoxic potentials of new medications and marketed drugs.
Chapter 30 is open access under a CC BY 4.0 license via link.springer.com.
Overview of Mechanisms of Drug-Induced Liver Injury (DILI) and Key Challenges in DILI Research
Noureddin, Nabil (et al.)
Pages 3-18
Detection, Elimination, Mitigation, and Prediction of Drug-Induced Liver Injury in Drug Discovery
Pognan, Francois
Pages 21-43
Drug-Induced Liver Injury (DILI) Classification and Its Application on Human DILI Risk Prediction
Thakkar, Shraddha (et al.)
Pages 45-59
Physicochemical Properties and Structural Alerts
Fisk, Lilia (et al.)
Pages 61-76
Quantitative Structure–Activity Relationship Models for Predicting Risk of Drug-Induced Liver Injury in Humans
Hong, Huixiao (et al.)
Pages 77-100
An Introduction to DILIsym® Software, a Mechanistic Mathematical Representation of Drug-Induced Liver Injury
Battista, Christina (et al.)
Pages 101-121
Prediction of Human Liver Toxicity Using In Vitro Assays: Limitations and Opportunities
Atienzar, Franck A. (et al.)
Pages 125-150
Use of Liver-Derived Cell Lines for the Study of Drug-Induced Liver Injury
Ren, Zhen (et al.)
Pages 151-177
Evaluation of Drug-Induced Liver Injuries (DILI) with Human Hepatocytes: Scientific Rationale and Experimental Approaches
Li, Albert P.
Pages 179-197
Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testing
Wong, Min Wei (et al.)
Pages 199-212
Engineered Human Liver Cocultures for Investigating Drug-Induced Liver Injury
Monckton, Chase P. (et al.)
Pages 213-248
Status and Future of 3D Cell Culture in Toxicity Testing
Otieno, Monicah A. (et al.)
Pages 249-261
Reactive Metabolite Assessment in Drug Discovery and Development in Support of Safe Drug Design
P?hler, Axel
Pages 263-281
In Vitro Assessment of Mitochondrial Toxicity to Predict Drug-Induced Liver Injury
Porceddu, Mathieu (et al.)
Pages 283-300
Bile Salt Export Pump: Drug-Induced Liver Injury and Assessment Approaches
Deng, Ruitang
Pages 301-329
High Content Screening for Prediction of Human Drug-Induced Liver Injury
Persson, Mikael
Pages 331-343
Interpretation, Integration, and Implementation of In Vitro Assay data: The Predictive Toxicity Challenge
Light, Deborah S. (et al.)
Pages 345-364
Perspectives on the Regulatory and Clinical Science of Drug-Induced Liver Injury (DILI)
Avigan, Mark I. (et al.)
Pages 367-393
Regulatory Toxicological Studies: Identifying Drug-Induced Liver Injury Using Nonclinical Studies
Khan, Imran (et al.)
Pages 395-410
Hy’s Law and eDISH for Clinical Studies
Senior, John (et al.)
Pages 411-429
Variability in Baseline Liver Test Values in Clinical Trials: Challenges in Enhancing Drug-Induced Liver Injury Assessment in Subjects with Liver Disease
Tesfaldet, Bereket (et al.)
Pages 431-457
Postmarketing Surveillance of Drug-Induced Liver Injury
Jones, S. Christopher (et al.)
Pages 459-474
Host Risk Modifiers in Idiosyncratic Drug-Induced Liver Injury (DILI) and Its Interplay with Drug Properties
Stephens, Camilla (et al.)
Pages 477-496
Human Leukocyte Antigen (HLA) and Other Genetic Risk Factors in Drug-Induced Liver Injury (DILI)
Daly, Ann K.
Pages 497-509
Immune Mechanisms in Drug-Induced Liver Injury
Jaeschke, Hartmut (et al.)
Pages 511-531
Translational and Mechanistic Biomarkers of Drug-Induced Liver Injury – Candidates and Qualification Strategies
Antoine, Daniel J.
Pages 533-553
Causality Assessment Methods in Drug-Induced Liver Injury
Teschke, Rolf (et al.)
Pages 555-594
Circulating MicroRNAs as Novel Biomarkers of Drug-Induced Liver Injury in Humans
Krauskopf, Julian (et al.)
Pages 597-610
Systems Microscopy Approaches in Unraveling and Predicting Drug-Induced Liver Injury (DILI)
Niemeijer, Marije (et al.)
Pages 611-625
Noninvasive Preclinical and Clinical Imaging of Liver Transporter Function Relevant to Drug-Induced Liver Injury
Kenna, J. Gerry (et al.)
Pages 627-651
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